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  • 產品名稱：Agitoxin-2

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Agitoxin-2
詳情介紹：
Purpose Agitoxin-2 is a potent blocker of Kv1.1 and Kv1.3 channels
Sequence AA sequence: Gly-Val-Pro-Ile-Asn-Val-Ser-Cys8-Thr-Gly -Ser-Pro-Gln-Cys14-Ile-Lys-Pro-Cys18-Lys-Asp- Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys28-Met-Asn -Arg-Lys-Cys33-His-Cys35-Thr-Pro-Lys-OH Disulfide bonds: Cys8-Cys28, Cys14-Cys33, Cys18-Cys35
Specificity Agitoxin-2 is a potent blocker of Kv1.1 and Kv1.3 channels
Characteristics Agitoxin-2 is a potent and selective blocker of the Shaker type voltage-gated Kv1.3 and Kv1.1 channels. Agitoxin-2 inhibits Kv1.3 with an IC50 value of around 200 pM and Kv1.1 with an IC50 value of around 140 pM. This peptide toxin was originally isolated from the venom of the Israeli scorpion L. quinquestriatus hebraeus.
Formula C169H278N54O48S8
Solubility water and saline buffer
Molecular Weight 4090.89 Da
CAS-No 168147-41-9
Restrictions For Research Use only
Format Powder
Storage -20 °C
Background publications Anangi, Koshy, Huq, Beeton, Chuang, King: "Recombinant expression of margatoxin and agitoxin-2 in Pichia pastoris: an efficient method for production of KV1.3 channel blockers." in: PLoS ONE, Vol. 7, Issue 12, pp. e52965, 2013 (PubMed).