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產品名稱：Caspase-4InhibitorZ-LEVD-FMK
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產品廠商：Biovision
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Caspase-4InhibitorZ-LEVD-FMK

詳情介紹：

Product details
Product details
Purpose	A caspase-4 inhibitor
Sequence	Z-Leu-Glu(OMe)-Val-Asp(OMe)-FMK
Characteristics	PubChem CID: 44135220 A synthetic peptide that irreversibly inhibits activity of LEVD-dependent caspases (e.g., caspase-4). The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can be used for both in vitro and in vivo studies. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
Purity	> 95?% by HPLC
Chemical Name	Z-LEVD-FMK, Caspase-4 Inhibitor (fluoromethylketone)
Formula	C??H??FN?O??
Permeability	Cell-permeable
Solubility	DMSO

Target details
Target details
Molecular Weight	652.7 g/mol

Application Details
Application Details
Application Notes	We recommend using 1000-5000X dilutions for inhibiting caspase-4 and related caspase activity (e.g., Add 1 μL to 1-5 mL of culture medium). However, the optimal doses may vary for different cells and culture conditions. The inhibitor is designed as a methyl ester to facilitate cell permeability.
Restrictions	For Research Use only

Handling
Handling
Format	Liquid
Concentration	10 mM
Handling Advice	Protect from light and moisture
Storage	-20 °C
Expiry Date	12 months

References
References
Product cited in:	Akamatsu, Shibata, Ito, Sohma, Azuma, Otsuki: "Riluzole induces apoptotic cell death in human prostate cancer cells via endoplasmic reticulum stress." in: Anticancer research, Vol. 29, Issue 6, pp. 2195-204, 2009 (PubMed). Chen, Jiang, Watts, Thorne, Kiejda, Zhang, Hersey: "Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein." in: Cancer research, Vol. 68, Issue 3, pp. 834-42, 2008 (PubMed). Jiang, Chen, Gillespie, Wang, Kiejda, Zhang, Hersey: "Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis." in: Cancer research, Vol. 67, Issue 20, pp. 9750-61, 2007 (PubMed). Kim, Zhang, Hitomi, Lee, Mukherjee: "Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL." in: Human molecular genetics, Vol. 15, Issue 11, pp. 1826-34, 2006 (PubMed). Gillet, Dewals, Farnir, de Leval, Vanderplasschen: "Bovine herpesvirus 4 induces apoptosis of human carcinoma cell lines in vitro and in vivo." in: Cancer research, Vol. 65, Issue 20, pp. 9463-72, 2005 (PubMed).