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  • 產品名稱：SwinholideA

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簡單介紹：
SwinholideA
詳情介紹：
Purity > 98 % (HPLC)
Background Swinholide A is a 44-carbon dimeric dilactone ring macrolide isolated from the marine sponge Theonella swinhoei. In vitro, it sequesters actin dimers with a binding stochiometry of 1:1, and it rapidly severs F-actin with high cooperativity. Swinholice A is potently cytotoxic by disruption of the actin cytoskeleton. It does not block progression of cells through the cell cycle, but does prevent cytokinesis. Cytotoxcity: Cell Type IC50 (μg/ml) KB Oral, epidermoid cell carcinoma 0.04 HT-1080 Fibrosarcoma 0.017 PC-3 Lung, adenocarcinoma 6.0 PC-9 Lung, adenocarcinoma 0.13 PC-10 Lung, squamous cell carcinoma 0.11 PC-13 Lung, large cell carcinoma 0.10 Daudi Burkitt lymphoma 0.036.
Molecular Weight 1388.9 Da
Application Notes Can be used in cell biology to distinguish between the effects induced by increasing intracellular concentrations of G-actin from those induced by a reduction in F-actin.
Comment

Formula: C78H132O20
Restrictions For Research Use only
Format Oil
Storage -20 °C
Background publications Saito, Watabe, Ozaki, Kobayashi, Suzuki, Kobayashi, Fusetani, Karaki: "Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A." in: Journal of biochemistry, Vol. 123, Issue 4, pp. 571-8, 1998 (PubMed).

Bubb, Spector: "Use of the F-actin-binding drugs, misakinolide A and swinholide A." in: Methods in enzymology, Vol. 298, pp. 26-32, 1998 (PubMed).

Lyubimova, Bershadsky, Ben-Zeev: "Autoregulation of actin synthesis responds to monomeric actin levels." in: Journal of cellular biochemistry, Vol. 65, Issue 4, pp. 469-78, 1997 (PubMed).

Bubb, Spector, Bershadsky, Korn: "Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments." in: The Journal of biological chemistry, Vol. 270, Issue 8, pp. 3463-6, 1995 (PubMed).