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Background
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This product is an antibiotic isolated from Streptomyces. It targets isoleucyl-tRNA synthetase and inhibits protein synthesis in eukaryotes. It has been investigated for its antitumor and antifungal activities. However, recent studies have revealed that low-dose of reveromycin A induces cell death of activated osteoclasts, which leads to acidic environment. Thus it receives attention as a candidate for the treatment of osteoporosis/ multiple myeloma.
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