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產(chǎn)品名稱：rCharybdotoxin
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產(chǎn)品廠商：BioLeaf
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rCharybdotoxin

詳情介紹：

Product details
Product details
Sequence	QFTNVSCTTS KECWSVCQRL HNTSRGKCMN KKCRCYS.
Specificity	Charybdotoxin is a potent selective inhibitor of high conductance (maxi-K), different medium and small conductance Ca2+-activated K+ channels, as well as a voltage-dependent K+ channel (Kv1.3).
Characteristics	Source: Leiurus quinquestriatus hebraeus (Yellow scorpion). Molecular formula: C₁₇₆H₂₈₀N₅₈O₅₅S₇. Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35.
Purity	> 98 %

Target details
Target details
Background	Inhibition of mSlo channels heterologously expressed in HEK293 cells by Charybdotoxin. mSlo channel currents, before and during application of 100nM rCharybdotoxin. The currents were activated by a 50 ms voltage step to +100 mV from a prepulse of -180 mV with intracellular 10M Ca2+.
Molecular Weight	4313

Application Details
Application Details
Application Notes	10-100 nM
Comment	K+ channel toxin -KTx 1.1, ChTX, ChTX-Lq1, ChTx-a.
Restrictions	For Research Use only

Handling
Handling
Format	Lyophilized
Reconstitution	Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min). Concentration after reconstitution: Dissolving 50g in 1.160ml will provide a stock solution of 10 M.
Handling Advice	Soluble in Water.

Images
Images
Supplier Images	mSlo channel currents, before and during application of 100nM rCharybdotoxin. The cur... mSlo channel currents, before and during application of 100nM rCharybdotoxin. The currents were activated by a 50 ms voltage step to +100 mV from a prepulse of -180 mV with intracellular 10μM Ca2+. mSlo channel currents, before and during application of 100nM rCharybdotoxin. The currents were activated by a 50 ms voltage step to +100 mV from a prepulse of -180 mV with intracellular 10μM Ca2+.

References
References
Background publications	Meera, Wallner, Toro: "A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 10, pp. 5562-7, 2000 (PubMed).
Product cited in:	Vita, Bontems, Bouet, Tauc, Poujeol, Vatanpour, Harvey, Menez, Toma: "Synthesis of charybdotoxin and of two N-terminal truncated analogues. Structural and functional characterisation." in: European journal of biochemistry / FEBS, Vol. 217, Issue 1, pp. 157-69, 1993 (PubMed). Gimenez-Gallego, Navia, Reuben, Katz, Kaczorowski, Garcia: "Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 10, pp. 3329-33, 1988 (PubMed). Smith, Phillips, Miller: "Purification of charybdotoxin, a specific inhibitor of the high-conductance Ca2+-activated K+ channel." in: The Journal of biological chemistry, Vol. 261, Issue 31, pp. 14607-13, 1986 (PubMed). Miller, Moczydlowski, Latorre, Phillips: "Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle." in: Nature, Vol. 313, Issue 6000, pp. 316-8, 1985 (PubMed).